5HEX

Crystal Structure of Human Hexokinase 2 with cmpd 30, a 2-amino-6-benzenesulfonamide glucosamine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Hexokinase-2	polymer	923	103102.5	2	UniProt (P52789) Pfam (PF00349) Pfam (PF03727)	Homo sapiens (Human)	Hexokinase type II,HK II,Muscle form hexokinase
2	C, D, E, F (A, B)	2-[(3-bromobenzene-1-carbonyl)amino]-6-{[(4-carboxy-5-methylfuran-2-yl)sulfonyl]amino}-2,6-dideoxy-alpha-D-glucopyranos e	non-polymer		549.3	4	Chemie (604)
3	G, H (A, B)	water	water		18.0	83	Chemie (HOH)

Sequence modifications

A, B: 17 - 917 (UniProt: P52789)

PDB	External Database	Details
Met -5	-	initiating methionine
Gly -4	-	expression tag
Ser -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
Ser 5	-	expression tag
Ser 6	-	expression tag
Gly 7	-	expression tag
Leu 8	-	expression tag
Glu 9	-	expression tag
Asn 10	-	expression tag
Leu 11	-	expression tag
Tyr 12	-	expression tag
Phe 13	-	expression tag
Gln 14	-	expression tag
Gly 15	-	expression tag
Ser 16	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	206205.0
Non-Polymers*	Number of molecules	4
	Total formula weight	2197.4
All*	Total formula weight	208402.4

*Water molecules are not included.