5HES
Human leucine zipper- and sterile alpha motif-containing kinase (ZAK, MLT, HCCS-4, MRK, AZK, MLTK) in complex with vemurafenib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Mitogen-activated protein kinase kinase kinase MLT | polymer | 307 | 35232.3 | 2 | UniProt (Q9NYL2) Pfam (PF07714) In PDB | Homo sapiens (Human) | Human cervical cancer suppressor gene 4 protein,HCCS-4,Leucine zipper- and sterile alpha motif-containing kinase,MLK-like mitogen-activated protein triple kinase,Mixed lineage kinase-related kinase,MRK,Sterile alpha motif- and leucine zipper-containing kinase AZK |
| 2 | A, B | N-(3-{[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl}-2,4-difluorophenyl)propane-1-sulfonamide | non-polymer | 489.9 | 2 | Chemie (032) | |||
| 3 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 179 | Chemie (HOH) |
Sequence modifications
A, B: 5 - 309 (UniProt: Q9NYL2)
| PDB | External Database | Details |
|---|---|---|
| Ser 3 | - | expression tag |
| Met 4 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70464.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1104.0 | |
| All* | Total formula weight | 71568.6 |
