5HEM
Crystal structure of the N-terminus D161Y bromodomain mutant of human BRD2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bromodomain-containing protein 2 | polymer | 126 | 14964.5 | 2 | UniProt (P25440) Pfam (PF00439) | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein |
| 2 | C, D, E, F, G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 3 | H, J (A, B) | ACETATE ION | non-polymer | 59.0 | 2 | Chemie (ACT) | |||
| 4 | I (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 214 | Chemie (HOH) |
Sequence modifications
A, B: 71 - 194 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Ser 69 | - | expression tag |
| Met 70 | - | expression tag |
| Tyr 161 | Asp 161 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29929.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 452.7 | |
| All* | Total formula weight | 30381.8 |
