5HE2

Bovine GRK2 in complex with Gbetagamma subunits and CCG224406

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Beta-adrenergic receptor kinase 1	polymer	641	74762.1	1	UniProt (P21146) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169) In PDB	Bos taurus (Bovine)	Beta-ARK-1, G-protein-coupled receptor kinase 2
2	B	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	339	37285.7	1	UniProt (P62873) Pfam (PF00400) In PDB	Homo sapiens (Human)	Transducin beta chain 1
3	G	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7845.1	1	UniProt (P59768) Pfam (PF00631) In PDB	Homo sapiens (Human)	G gamma-I
4	A	(4~{S})-4-[3-[(2,6-dimethoxyphenyl)methylcarbamoyl]-4-fluoranyl-phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide	non-polymer		558.6	1	Chemie (F0S)
5		water	water		18.0	31	Chemie (HOH)

Sequence modifications

A: 30 - 670 (UniProt: P21146)

PDB	External Database	Details
Ala 670	Ser 670	engineered mutation

G: 1 - 71 (UniProt: P59768)

PDB	External Database	Details
Ser 68	Cys 68	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	119892.9
Non-Polymers*	Number of molecules	1
	Total formula weight	558.6
All*	Total formula weight	120451.5

*Water molecules are not included.