5HDO

Crystal structure of a nanobody raised against urokinase-type plasminogen activator

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Anti-HCV NS3/4A serine protease immoglobulin heavy chain	polymer	128	13598.0	4	UniProt (A0A0F6YEF6) Pfam (PF07686)	Camelus dromedarius (Dromedary)
2	E, F, H, J (A, B, C, D)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	G, I, K, L (B, C, D)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
4	M, N, O, P (A, B, C, D)	water	water		18.0	460	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 127 (UniProt: A0A0F6YEF6)

PDB	External Database	Details
Gln 1	Glu 1	conflict
Gln 5	Val 5	conflict
Leu 11	Ser 11	conflict
Phe 27	Tyr 27	conflict
Leu 29	Tyr 29	conflict
Asp 30	Cys 30	conflict
Ala 33	Gly 33	conflict
Ile 34	Met 34	conflict
Gly 35	Ser 35	conflict
Phe 37	Tyr 37	conflict
Gly 47	Phe 47	conflict
Cys 50	Ala 50	conflict
Ser 52	-	insertion
Ala 53	Asp 52	conflict
Gly 55	Asp 54	conflict
Asn 59	Ser 58	conflict
Arg 72	Gln 71	conflict
Lys 87	Ile 86	conflict
Ser 88	Pro 87	conflict
Val 93	Met 92	conflict
Ala 97	Lys 96	conflict
Ala 98	Thr 97	conflict
His 100	Gln 99	conflict
Pro 101	Thr 100	conflict
Leu 103	-	insertion
Cys 104	-	insertion
Thr 105	Gly 102	conflict
Glu 107	Trp 104	conflict
Ser 108	Trp 105	conflict
Gly 109	Ala 106	conflict
Arg 110	Asp 107	conflict
Arg 111	Cys 108	conflict
Gln 122	Met 119	conflict
Ala 128	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	54391.8
Non-Polymers*	Number of molecules	8
	Total formula weight	526.1
All*	Total formula weight	54917.9

*Water molecules are not included.