5HBJ

CDK8-CYCC IN COMPLEX WITH 8-[2-Amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-pyridin-4-yl]-2,8-diaza-spiro[4.5]decan-1-one

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclin-dependent kinase 8	polymer	364	42552.2	1	UniProt (P49336) Pfam (PF00069) In PDB	Homo sapiens (Human)	Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35
2	B	Cyclin-C	polymer	270	32001.5	1	UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB	Homo sapiens (Human)	SRB11 homolog,hSRB11
3	A	8-[2-azanyl-3-chloranyl-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	non-polymer		410.9	1	Chemie (5Y8)
4	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	B	FORMIC ACID	non-polymer		46.0	1	Chemie (FMT)
6		water	water		18.0	16	Chemie (HOH)

Sequence modifications

A: 1 - 362 (UniProt: P49336)

PDB	External Database	Details
Asp -1	-	expression tag
Lys 0	-	expression tag

B: 1 - 264 (UniProt: P24863)

PDB	External Database	Details
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Lys -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74553.7
Non-Polymers*	Number of molecules	3
	Total formula weight	519.0
All*	Total formula weight	75072.7

*Water molecules are not included.