5HBE
CDK8-CYCC IN COMPLEX WITH 8-[3-Chloro-5-(1-methyl-2,2-dioxo-2, 3-dihydro-1H-2l6-benzo[c]isothiazol-5-yl)-pyridin- 4-yl]-1-oxa-3,8-diaza-spiro[4.5]decan-2-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cyclin-dependent kinase 8 | polymer | 364 | 42552.2 | 1 | UniProt (P49336) Pfam (PF00069) In PDB | Homo sapiens (Human) | Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35 |
| 2 | B | Cyclin-C | polymer | 266 | 31541.1 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB | Homo sapiens (Human) | SRB11 homolog,hSRB11 |
| 3 | A | 8-[3-chloranyl-5-[1-methyl-2,2-bis(oxidanylidene)-3~{H}-2,1-benzothiazol-5-yl]pyridin-4-yl]-1-oxa-3,8-diazaspiro[4.5]decan-2-one | non-polymer | 448.9 | 1 | Chemie (5Y6) | |||
| 4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | A, B | FORMIC ACID | non-polymer | 46.0 | 4 | Chemie (FMT) | |||
| 7 | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
A: 1 - 362 (UniProt: P49336)
B: 1 - 264 (UniProt: P24863)
| PDB | External Database | Details |
|---|---|---|
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Lys -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74093.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 773.2 | |
| All* | Total formula weight | 74866.6 |
