5H8H

Structure of the human GluN1/GluN2A LBD in complex with GNE3419

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Glutamate receptor ionotropic, NMDA 2A,Glutamate receptor ionotropic, NMDA 2A	polymer	285	31883.4	1	UniProt (Q12879) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (Human)	GluN2A, Glutamate [NMDA] receptor subunit epsilon-1, N-methyl D-aspartate receptor subtype 2A, hNR2A
2	B (B)	Glutamate receptor ionotropic, NMDA 1,Glutamate receptor ionotropic, NMDA 1	polymer	293	33409.1	1	UniProt (Q05586) Pfam (PF10613) Pfam (PF00060)	Homo sapiens (Human)	GluN1, Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1
3	C (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
4	D (A)	GLUTAMIC ACID	non-polymer		147.1	1	Chemie (GLU)
5	E (B)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
6	F (B)	GLYCINE	non-polymer		75.1	1	Chemie (GLY)
7	G (B)	7-[[ethyl(phenyl)amino]methyl]-2-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one	non-polymer		300.4	1	Chemie (5YC)
8	H, I (A, B)	water	water		18.0	146	Chemie (HOH)

Sequence modifications

A: 3 - 141 (UniProt: Q12879)

PDB	External Database	Details
Gly 1	-	expression tag
Ser 2	-	expression tag

A: 144 - 285 (UniProt: Q12879)

PDB	External Database	Details
Gly 142	-	linker
Thr 143	-	linker

B: 3 - 153 (UniProt: Q05586)

PDB	External Database	Details
Gly 1	-	expression tag
Ser 2	-	expression tag

B: 156 - 293 (UniProt: Q05586)

PDB	External Database	Details
Gly 154	-	linker
Thr 155	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65292.5
Non-Polymers*	Number of molecules	5
	Total formula weight	621.7
All*	Total formula weight	65914.2

*Water molecules are not included.