5H2U
Crystal structure of PTK6 Kinase Domain complexed with Dasatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Protein-tyrosine kinase 6 | polymer | 267 | 30864.6 | 4 | UniProt (Q13882) Pfam (PF07714) | Homo sapiens (Human) | Breast tumor kinase,Tyrosine-protein kinase BRK |
| 2 | E, I, M, T (A, B, C, D) | N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE | non-polymer | 488.0 | 4 | Chemie (1N1) | |||
| 3 | F, G, H, J, K... (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 12 | Chemie (GOL) | |||
| 4 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 501 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 185 - 446 (UniProt: Q13882)
| PDB | External Database | Details |
|---|---|---|
| Cxm 184 | - | expression tag |
| Thr 433 | Cys 433 | engineered mutation |
| His 447 | - | expression tag |
| His 448 | - | expression tag |
| His 449 | - | expression tag |
| His 450 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 123458.5 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 3057.2 | |
| All* | Total formula weight | 126515.6 |
