5H0V

Crystal structure of H88A mutated human transthyretin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Transthyretin	polymer	126	13909.5	4	UniProt (P02766) Pfam (PF00576)	Homo sapiens (Human)	ATTR,Prealbumin,TBPA
2	E, G (A, D)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	2	Chemie (MPD)
3	F (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	H, I, J, K (A, B, C, D)	water	water		18.0	440	Chemie (HOH)

Sequence modifications

A, B, C, D: 11 - 127 (UniProt: P02766)

PDB	External Database	Details
Ala 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
Met 9	-	expression tag
Ser 10	-	expression tag
Ala 88	His 108	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	55638.1
Non-Polymers*	Number of molecules	3
	Total formula weight	260.7
All*	Total formula weight	55898.8

*Water molecules are not included.