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5GW6

Water-Bridge Mediates Recognition of mRNA Cap in eIF4E

Replaces:  5ABI
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AEukaryotic translation initiation factor 4Epolymer19622703.61UniProt (P06730)
Pfam (PF01652)
In PDB
Homo sapiens (Human)eIF4E,eIF-4F 25 kDa subunit,mRNA cap-binding protein
2AGLYCEROLnon-polymer92.13Chemie (GOL)
3waterwater18.0101Chemie (HOH)
Sequence modifications
A: 23 - 217 (UniProt: P06730)
PDBExternal DatabaseDetails
Met 22-initiating methionine
Ala 105Glu 105engineered mutation
Ala 106Lys 106engineered mutation
Ala 108Lys 108engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight22703.6
Non-Polymers*Number of molecules3
Total formula weight276.3
All*Total formula weight22979.9
*Water molecules are not included.

222415

PDB entries from 2024-07-10

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