5GPG

Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB domain of human mTOR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Peptidyl-prolyl cis-trans isomerase FKBP3	polymer	117	13047.0	1	UniProt (Q00688) Pfam (PF00254)	Homo sapiens (Human)	PPIase FKBP3,25 kDa FK506-binding protein,FKBP-25,FK506-binding protein 3,FKBP-3,Immunophilin FKBP25,Rapamycin-selective 25 kDa immunophilin,Rotamase
2	B (B)	Serine/threonine-protein kinase mTOR	polymer	93	11352.8	1	UniProt (P42345) Pfam (PF08771)	Homo sapiens (Human)	FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1
3	C (A)	RAPAMYCIN IMMUNOSUPPRESSANT DRUG	non-polymer		914.2	1	Chemie (RAP) PubChem (21944094) PubChem (22524702) PubChem (22524747) PubChem (22525359) PubChem (176856347) PubChem (23351774) PubChem (23375411) PubChem (23376986) PubChem (23748515) PubChem (24870962) PubChem (24871327) PubChem (25200053) PubChem (25200063) PubChem (44120108) PubChem (16760052) PubChem (16760631) PubChem (17753749) PubChem (44476572) PubChem (44634693) PubChem (21176130) PubChem (21549991) PubChem (21863017) PubChem (22524575) PubChem (22525016) PubChem (22771180) PubChem (22829016) PubChem (23351773) PubChem (23375412) PubChem (23376988) PubChem (24150662) PubChem (24867259) PubChem (24871317) PubChem (25200284) PubChem (25200075) PubChem (25200308) PubChem (25266201) PubChem (54600319) PubChem (57579211) PubChem (57831856) PubChem (44295234) PubChem (58597069) PubChem (58597081) PubChem (58651220) PubChem (58651224) PubChem (58682959) PubChem (58725682) PubChem (58725688) PubChem (58731856) PubChem (58757256) PubChem (58818830) PubChem (58942911) PubChem (59079213) PubChem (59116632) PubChem (59262957) PubChem (44634703) PubChem (59716030) PubChem (59746150) PubChem (59761584) PubChem (59798735) PubChem (46835353) PubChem (59976377) PubChem (49652385) PubChem (70789198) PubChem (71296106) PubChem (53298413) PubChem (53627520) PubChem (478951) PubChem (73265225) PubChem (73438908) PubChem (145684635) PubChem (57312764) PubChem (57549339) PubChem (57747481) PubChem (57654444) PubChem (73896879) PubChem (57542109) PubChem (57831854) PubChem (58651218) PubChem (58731853) PubChem (58863407) PubChem (58681233) PubChem (58651217) PubChem (58682966) PubChem (58725690) PubChem (59032409) PubChem (59111212) PubChem (59079212) PubChem (59189008) PubChem (59584560) PubChem (59873116) PubChem (59741796) PubChem (59514927) PubChem (59695672) PubChem (59762850) PubChem (59716029) PubChem (59746146) PubChem (59798734) PubChem (59836921) PubChem (59762848) PubChem (59939263) PubChem (59843436) PubChem (60084327) PubChem (59965662) PubChem (59921726) PubChem (59972802) PubChem (59982608) PubChem (60003176) PubChem (60148419) PubChem (60146796) PubChem (86583604) PubChem (60150249) PubChem (88543353) PubChem (88877093) PubChem (88877541) PubChem (88982079) PubChem (143131348) PubChem (176481738) PubChem (89172501) PubChem (89222646) PubChem (89229297) PubChem (89288626) PubChem (176797660) PubChem (176878509) PubChem (177257072) PubChem (177410779) PubChem (5040) PubChem (65448) PubChem (90660428) PubChem (90660646) PubChem (313006) PubChem (71308609) PubChem (71463321) PubChem (73438890) PubChem (73707374) PubChem (73952167) PubChem (87199396) PubChem (87413824) PubChem (88877157) PubChem (88876970) PubChem (88938482) PubChem (88934904) PubChem (89164572) PubChem (89173639) PubChem (89263866) PubChem (89193790) PubChem (89203820) PubChem (89203981) PubChem (89382243) PubChem (89651883) PubChem (89691897) PubChem (91157894) PubChem (90830213) PubChem (90954095) PubChem (91059082) PubChem (91312280) PubChem (91407558) PubChem (5358081) PubChem (5284616) PubChem (98042555) PubChem (99726904) PubChem (99726905) PubChem (99719687) PubChem (99726902) PubChem (99719685) PubChem (101058122) PubChem (5374464) PubChem (5460439) PubChem (5497196) PubChem (5924240) PubChem (118028380) PubChem (6610346) PubChem (6711160) PubChem (6713081) PubChem (123319649) PubChem (123375319) PubChem (123284252) PubChem (123579029) PubChem (123745020) PubChem (123961550) PubChem (124202144) PubChem (124202163) PubChem (9833581) PubChem (9854379) PubChem (124923869) PubChem (125182984) PubChem (9962926) PubChem (126706235) PubChem (6436030) PubChem (129018336) PubChem (10213190) PubChem (129396805) PubChem (131674889) PubChem (131668123) PubChem (132342626) PubChem (6610270) PubChem (133550001) PubChem (99719686) PubChem (99726903) PubChem (118701644) PubChem (118968446) PubChem (134812764) PubChem (11959112) PubChem (9854380) PubChem (136197703) PubChem (137146980) PubChem (137126527) PubChem (9962928) PubChem (137154395) PubChem (137154392) PubChem (137154394) PubChem (137159082) PubChem (137303712) PubChem (137321130) PubChem (123132513) PubChem (123685353) PubChem (137513797) PubChem (123966602) PubChem (124202326) PubChem (140457701) PubChem (140509544) PubChem (140495012) PubChem (141827210) PubChem (11949238) PubChem (13003162) PubChem (146165671) PubChem (149030593) PubChem (149030595) PubChem (154539809) PubChem (155923785) PubChem (154575194) PubChem (124923870) PubChem (124923871) PubChem (124923872) PubChem (157691735) PubChem (158004723) PubChem (158004725) PubChem (158667905) PubChem (158667900) PubChem (159512395) PubChem (160401076) PubChem (160401082) PubChem (160401068) PubChem (160843420) PubChem (160401063) PubChem (160401067) PubChem (160401073) PubChem (160843418) PubChem (160401077) PubChem (160559912) PubChem (161552714) PubChem (162393098) PubChem (162702738) PubChem (162907223) PubChem (162907225) PubChem (162907221) PubChem (163193694) PubChem (163359781) PubChem (163895655) PubChem (163895656) PubChem (163978502) PubChem (166639084) PubChem (167403487) PubChem (168267583) PubChem (168314647) PubChem (168843998) PubChem (168810792) PubChem (169766759) PubChem (170922362) PubChem (170996834) PubChem (171042528) PubChem (171329380) PubChem (171360948) PubChem (171607084) PubChem (171991699) PubChem (129010340) PubChem (173549023) PubChem (173303291) PubChem (173381240) PubChem (173209376) PubChem (173484164) PubChem (173477043) PubChem (173523625) PubChem (173644621) PubChem (173628231) PubChem (173732063) PubChem (173790728) PubChem (174051096) PubChem (174079707) PubChem (174086051) PubChem (175963732) PubChem (129150908) PubChem (134129699) PubChem (134572840) PubChem (134760597) PubChem (137146981) PubChem (137146982) PubChem (137154393) PubChem (137244727) PubChem (137795242) PubChem (138106895) PubChem (138404388) PubChem (140456940) PubChem (140495013) PubChem (140504269) PubChem (149030591) PubChem (149030592) PubChem (149030594) PubChem (153274811) PubChem (153484733) PubChem (154547638) PubChem (157502692) PubChem (157507229) PubChem (160401064) PubChem (160401065) PubChem (160401066) PubChem (160401069) PubChem (160401070) PubChem (160401071) PubChem (160401072) PubChem (160401074) PubChem (160401075) PubChem (160401078) PubChem (160401079) PubChem (160401080) PubChem (160401081) PubChem (161095401) PubChem (161095402) PubChem (161418798) PubChem (162907222) PubChem (162907224) PubChem (163895657) PubChem (166604446) PubChem (168311769) PubChem (169962415) PubChem (171125838) PubChem (171159772) PubChem (171703108) PubChem (171761843) PubChem (172017404) PubChem (172018138) PubChem (172503251) PubChem (173075346) PubChem (173296700) PubChem (173303290) PubChem (173303292) PubChem (173303664) PubChem (173382757) PubChem (173481203) PubChem (173493552) PubChem (173512554) PubChem (173614191) PubChem (173682385) PubChem (175673538) PubChem (175737102) PubChem (176418841)
4	D, E (A, B)	water	water		18.0	288	Chemie (HOH)

Sequence modifications

A: 109 - 224 (UniProt: Q00688)

PDB	External Database	Details
Ser 108	-	expression tag

B: 2021 - 2112 (UniProt: P42345)

PDB	External Database	Details
Ser 2020	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	24399.8
Non-Polymers*	Number of molecules	1
	Total formula weight	914.2
All*	Total formula weight	25314.0

*Water molecules are not included.