5GPG
Co-crystal structure of the FK506 binding domain of human FKBP25, Rapamycin and the FRB domain of human mTOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Peptidyl-prolyl cis-trans isomerase FKBP3 | polymer | 117 | 13047.0 | 1 | UniProt (Q00688) Pfam (PF00254) | Homo sapiens (Human) | PPIase FKBP3,25 kDa FK506-binding protein,FKBP-25,FK506-binding protein 3,FKBP-3,Immunophilin FKBP25,Rapamycin-selective 25 kDa immunophilin,Rotamase |
| 2 | B (B) | Serine/threonine-protein kinase mTOR | polymer | 93 | 11352.8 | 1 | UniProt (P42345) Pfam (PF08771) | Homo sapiens (Human) | FK506-binding protein 12-rapamycin complex-associated protein 1,FKBP12-rapamycin complex-associated protein,Mammalian target of rapamycin,mTOR,Mechanistic target of rapamycin,Rapamycin and FKBP12 target 1,Rapamycin target protein 1 |
| 3 | C (A) | RAPAMYCIN IMMUNOSUPPRESSANT DRUG | non-polymer | 914.2 | 1 | Chemie (RAP) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 288 | Chemie (HOH) |
Sequence modifications
A: 109 - 224 (UniProt: Q00688)
B: 2021 - 2112 (UniProt: P42345)
| PDB | External Database | Details |
|---|---|---|
| Ser 108 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 2020 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24399.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 914.2 | |
| All* | Total formula weight | 25314.0 |
