5GMH
Crystal structure of monkey TLR7 in complex with R848
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Toll-like receptor 7 | polymer | 817 | 94014.7 | 2 | UniProt (B3Y653) Pfam (PF13855) | Macaca mulatta (Rhesus macaque) | Uncharacterized protein |
| 2 | C, D, E (C, D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 3 | EA, F (B, A) | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol | non-polymer | 314.4 | 2 | Chemie (RX8) | |||
| 4 | FA, G, GA, H, HA... (B, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 12 | Chemie (NAG) | |||
| 5 | AA, BA, CA, DA, KA... (A, B) | SULFATE ION | non-polymer | 96.1 | 28 | Chemie (SO4) | |||
| 6 | VA, WA (A, B) | water | water | 18.0 | 653 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 839 (UniProt: B3Y653)
| PDB | External Database | Details |
|---|---|---|
| Arg 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Pro 25 | - | expression tag |
| Trp 26 | - | expression tag |
| Gln 167 | Asn 167 | engineered mutation |
| Gln 389 | Asn 389 | engineered mutation |
| Gln 488 | Asn 488 | engineered mutation |
| Gln 799 | Asn 799 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 188029.3 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1273.2 | |
| Non-Polymers* | Number of molecules | 42 |
| Total formula weight | 5973.0 | |
| All* | Total formula weight | 195275.5 |
