5GJV
Structure of the mammalian voltage-gated calcium channel Cav1.1 complex at near atomic resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Voltage-dependent L-type calcium channel subunit alpha-1S | polymer | 1873 | 212240.6 | 1 | UniProt (P07293) Pfam (PF00520) Pfam (PF08016) Pfam (PF16905) Pfam (PF08763) Pfam (PF16885) | Oryctolagus cuniculus (Rabbit) | Calcium channel,L type,alpha-1 polypeptide,isoform 3,skeletal muscle,Voltage-gated calcium channel subunit alpha Cav1.1 |
| 2 | B (B) | Voltage-dependent L-type calcium channel subunit beta-1 | polymer | 106 | 11974.7 | 1 | UniProt (P19517) Pfam (PF12052) | Oryctolagus cuniculus (Rabbit) | CAB1,Calcium channel voltage-dependent subunit beta 1 |
| 3 | C (C) | Voltage-dependent L-type calcium channel subunit beta-1 | polymer | 199 | 22356.8 | 1 | UniProt (P19517) Pfam (PF00625) | Oryctolagus cuniculus (Rabbit) | CAB1,Calcium channel voltage-dependent subunit beta 1 |
| 4 | D (E) | Voltage-dependent calcium channel gamma-1 subunit | polymer | 222 | 25082.3 | 1 | UniProt (P19518) Pfam (PF13903) | Oryctolagus cuniculus (Rabbit) | Dihydropyridine-sensitive L-type,skeletal muscle calcium channel subunit gamma |
| 5 | E (F) | Voltage-dependent calcium channel subunit alpha-2/delta-1 | polymer | 1106 | 125156.0 | 1 | UniProt (P13806) Pfam (PF08399) Pfam (PF00092) Pfam (PF08473) | Oryctolagus cuniculus (Rabbit) | Voltage-gated calcium channel subunit alpha-2/delta-1 |
| 6 | F, G, J, K (D, G, J, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 7 | H, I (H, I) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 8 | L (L) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 1 | In PDB BIRD (PRD_900017) GlyTouCan (G47362BJ) | triacetyl-beta-chitotriose | ||
| 9 | DA, EA, FA, GA, HA... (F, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 10 | AA, N, O, P, Q... (A) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 14 | Chemie (PC1) | |||
| 11 | BA, CA, KA (A, F) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) |
Sequence modifications
B: 80 - 174 (UniProt: P19517)
F: 1 - 1106 (UniProt: P13806)
| PDB | External Database | Details |
|---|---|---|
| Ser 69 | - | expression tag |
| Leu 70 | - | expression tag |
| Glu 71 | - | expression tag |
| Val 72 | - | expression tag |
| Leu 73 | - | expression tag |
| Phe 74 | - | expression tag |
| Gln 75 | - | expression tag |
| Gly 76 | - | expression tag |
| Pro 77 | - | expression tag |
| His 78 | - | expression tag |
| Met 79 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Eta 1075 | Gly 1075 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 396810.4 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 3498.3 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 12951.9 | |
| All* | Total formula weight | 413260.6 |
