5GGZ
Crystal structure of novel inhibitor bound with Hsp90
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, A, D, C | Heat shock protein HSP 90-alpha | polymer | 210 | 23549.8 | 4 | UniProt (P07900) Pfam (PF13589) In PDB | Homo sapiens (Human) | Hsp90 |
| 2 | B, A, D, C | [2,4-bis(oxidanyl)-5-propan-2-yl-phenyl]-(2-ethoxy-7,8-dihydro-5~{H}-pyrido[4,3-d]pyrimidin-6-yl)methanone | non-polymer | 357.4 | 4 | Chemie (6TN) | |||
| 3 | water | water | 18.0 | 409 | Chemie (HOH) |
Sequence modifications
B, A, D, C: 16 - 225 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| Val 126 | Ala 126 | See Sequence details |
| Lys 225 | Glu 225 | See Sequence details |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 94199.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1429.6 | |
| All* | Total formula weight | 95628.6 |
