5G04
Structure of the human APC-Cdc20-Hsl1 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 | polymer | 1944 | 216725.5 | 1 | UniProt (Q9H1A4) Pfam (PF12859) Pfam (PF20518) Pfam (PF21282) Pfam (PF18122) In PDB | HOMO SAPIENS (HUMAN) | APC1, CYCLOSOME SUBUNIT 1, MITOTIC CHECKPOINT REGULATOR, TESTIS-SPECIFIC GENE 24 PROTEIN, APC1 |
| 2 | B | ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 | polymer | 84 | 9854.6 | 1 | UniProt (Q9NYG5) Pfam (PF12861) In PDB | HOMO SAPIENS (HUMAN) | APC11, CYCLOSOME SUBUNIT 11, HEPATOCELLULAR CARCINOMA-ASSOCIATED RING FINGER PROTEIN, APC11 |
| 3 | C, P | CELL DIVISION CYCLE PROTEIN 23 HOMOLOG | polymer | 597 | 68921.0 | 2 | UniProt (Q9UJX2) Pfam (PF04049) In PDB | HOMO SAPIENS (HUMAN) | ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, APC8, CYCLOSOME SUBUNIT 8, APC8 |
| 4 | D | ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 | polymer | 121 | 14286.7 | 1 | UniProt (P60006) Pfam (PF15243) In PDB | HOMO SAPIENS (HUMAN) | APC15 |
| 5 | E | ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 | polymer | 110 | 11678.0 | 1 | UniProt (Q96DE5) Pfam (PF17256) In PDB | HOMO SAPIENS (HUMAN) | APC16, CYCLOSOME SUBUNIT 16, APC16 |
| 6 | F, H | CELL DIVISION CYCLE PROTEIN 27 HOMOLOG | polymer | 824 | 91973.1 | 2 | UniProt (P30260) Pfam (PF12895) Pfam (PF00515) In PDB | HOMO SAPIENS (HUMAN) | ANAPHASE-PROMOTING COMPLEX SUBUNIT 3, APC3, CDC27 HOMOLOG, CDC27HS, H-NUC, APC3 |
| 7 | G, W | ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 | polymer | 85 | 9794.0 | 2 | UniProt (Q8NHZ8) Pfam (PF10471) In PDB | HOMO SAPIENS (HUMAN) | ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG, APC12 |
| 8 | I | ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 | polymer | 808 | 92219.2 | 1 | UniProt (Q9UJX5) Pfam (PF12894) Pfam (PF12896) In PDB | HOMO SAPIENS (HUMAN) | APC4, CYCLOSOME SUBUNIT 4, APC4 |
| 9 | J, K | CELL DIVISION CYCLE PROTEIN 16 HOMOLOG | polymer | 620 | 71747.5 | 2 | UniProt (Q13042) Pfam (PF12895) Pfam (PF13424) In PDB | HOMO SAPIENS (HUMAN) | ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6, APC6 |
| 10 | L | ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 | polymer | 184 | 21124.9 | 1 | UniProt (Q9UM13) Pfam (PF03256) In PDB | HOMO SAPIENS (HUMAN) | APC10, CYCLOSOME SUBUNIT 10, APC10 |
| 11 | M | ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 | polymer | 74 | 8528.3 | 1 | UniProt (Q9BS18) Pfam (PF05839) In PDB | HOMO SAPIENS (HUMAN) | APC13, CYCLOSOME SUBUNIT 13, APC13 |
| 12 | N | ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 | polymer | 822 | 93939.0 | 1 | UniProt (Q9UJX6) Pfam (PF00888) Pfam (PF08672) In PDB | HOMO SAPIENS (HUMAN) | APC2, CYCLOSOME SUBUNIT 2, APC2 |
| 13 | O | ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 | polymer | 755 | 85179.8 | 1 | UniProt (Q9UJX4) Pfam (PF21371) Pfam (PF12862) In PDB | HOMO SAPIENS (HUMAN) | APC5, CYCLOSOME SUBUNIT 5, APC5 |
| 14 | R | CELL DIVISION CYCLE PROTEIN 20 HOMOLOG | polymer | 499 | 54796.5 | 1 | UniProt (Q12834) Pfam (PF12894) Pfam (PF00400) In PDB | HOMO SAPIENS (HUMAN) | P55CDC, CDC20 |
| 15 | S | PROBABLE SERINE/THREONINE-PROTEIN KINASE HSL1 | polymer | 206 | 23658.2 | 1 | UniProt (P34244) In PDB | SACCHAROMYCES CEREVISIAE (BAKER'S YEAST) | HSL1 |
| 16 | X, Y | ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 | polymer | 599 | 66929.4 | 2 | UniProt (Q9UJX3) Pfam (PF13181) Pfam (PF13432) In PDB | HOMO SAPIENS (HUMAN) | APC7, CYCLOSOME SUBUNIT 7, APC7 |
| 17 | B | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence modifications
L: 1 - 184 (UniProt: Q9UM13)
| PDB | External Database | Details |
|---|---|---|
| - | Arg 172 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 21 |
| Total formula weight | 1250720.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 196.2 | |
| All* | Total formula weight | 1250917.0 |
