5FWY

Crystal structure of the AMPA receptor GluA2/A3 N-terminal domain heterodimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	GLUTAMATE RECEPTOR 2	polymer	385	43731.4	2	UniProt (P19491) Pfam (PF01094)	RATTUS NORVEGICUS (NORWAY RAT)	GLUR-2, AMPA-SELECTIVE GLUTAMATE RECEPTOR 2, GLUR-B, GLUR-K 2, GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2, GLUA2, GLUA2 AMPA RECEPT OR N-TERMINAL DOMAIN
2	B, D (B, D)	GLUTAMATE RECEPTOR 3	polymer	390	45094.0	2	UniProt (P19492) Pfam (PF01094)	RATTUS NORVEGICUS (NORWAY RAT)	GLUR-3, AMPA-SELECTIVE GLUTAMATE RECEPTOR 3, GLUR-C, GLUR-K 3, GLUTAMATE RECEPTOR IONOTROPIC, AMPA 3, GLUA3, GLUA3 AMPA RECEPT OR N-TERMINAL DOMAIN
3	E, F, H, I, J... (A, B, C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	10	Chemie (NAG)
4	G, K, L, N, O... (A, B, C, D)	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
5	M (B)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	AA, X, Y, Z (D, A, B, C)	water	water		18.0	352	Chemie (HOH)

Sequence modifications

A, C: 4 - 379 (UniProt: P19491)

PDB	External Database	Details
Arg 380	-	expression tag
Thr 381	-	expression tag
Lys 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag

B, D: 1 - 381 (UniProt: P19492)

PDB	External Database	Details
Gly 382	-	expression tag
Thr 383	-	expression tag
Lys 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag
His 390	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	177650.6
Non-Polymers*	Number of molecules	19
	Total formula weight	3072.7
All*	Total formula weight	180723.3

*Water molecules are not included.