5FWX

Crystal structure of the AMPA receptor GluA2/A4 N-terminal domain heterodimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	GLUTAMATE RECEPTOR 2	polymer	385	43731.4	2	UniProt (P19491) Pfam (PF01094)	RATTUS NORVEGICUS (NORWAY RAT)	GLUR-2, AMPA-SELECTIVE GLUTAMATE RECEPTOR 2, GLUR-B, GLUR-K 2, GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2, GLUA2, GLUA2 AMPA RECEPTOR N-TERMINAL DOMAIN
2	B, D (B, D)	GLUTAMATE RECEPTOR 4	polymer	389	44547.4	2	UniProt (P19493) Pfam (PF01094)	RATTUS NORVEGICUS (NORWAY RAT)	GLUR-4, GLUR4, AMPA-SELECTIVE GLUTAMATE RECEPTOR 4, GLUR-D, GLUTAMATE RECEPTOR IONOTROPIC, AMPA 4, GLUA4, GLUA4 AMPA RECEPTOR N-TERMINAL DOMAIN
3	E, G, I, J (A, B, C, D)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
4	F, H, K (A, B, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
5	L, M, N, O (A, B, C, D)	water	water		18.0	125	Chemie (HOH)

Sequence modifications

A, C: 4 - 379 (UniProt: P19491)

PDB	External Database	Details
Arg 380	-	expression tag
Thr 381	-	expression tag
Lys 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag

B, D: 1 - 380 (UniProt: P19493)

PDB	External Database	Details
Arg 381	-	expression tag
Thr 382	-	expression tag
Lys 383	-	expression tag
His 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	176557.6
Non-Polymers*	Number of molecules	7
	Total formula weight	1047.9
All*	Total formula weight	177605.5

*Water molecules are not included.