5FWL

Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	HEAT SHOCK PROTEIN HSP 90 BETA	polymer	727	83645.5	2	UniProt (P08238) Pfam (PF13589) Pfam (PF00183)	HOMO SAPIENS (HUMAN)	HSP 90, HEAT SHOCK 84 KDA, HSP 84, HSP84, HEAT SHOCK PROTEIN HSP 90 BETA
2	C (E)	HSP90 CO-CHAPERONE CDC37	polymer	378	44622.4	1	UniProt (Q16543) Pfam (PF03234) Pfam (PF08565) Pfam (PF08564)	HOMO SAPIENS (HUMAN)	HSP90 CHAPERONE PROTEIN KINASE-TARGETING SUBUNIT, P50CDC37
3	D (K)	CYCLIN-DEPENDENT KINASE 4	polymer	310	34520.6	1	UniProt (P11802) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	CELL DIVISION PROTEIN KINASE 4, PSK-J3
4	E, G (A, B)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)
5	F, H (A, B)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)

Sequence modifications

A, B: 1 - 724 (UniProt: P08238)

PDB	External Database	Details
Gly -2	-	expression tag
Gly -1	-	expression tag
Phe 0	-	expression tag

K: 1 - 303 (UniProt: P11802)

PDB	External Database	Details
Gly -6	-	expression tag
Ala -5	-	expression tag
Met -4	-	expression tag
Asp -3	-	expression tag
Pro -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	246434.1
Non-Polymers*	Number of molecules	4
	Total formula weight	1063.0
All*	Total formula weight	247497.0

*Water molecules are not included.