5FN3
Cryo-EM structure of gamma secretase in class 1 of the apo- state ensemble
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nicastrin | polymer | 709 | 78483.6 | 1 | UniProt (Q92542) Pfam (PF18266) Pfam (PF05450) | Homo sapiens (Human) | |
| 2 | B (B) | Presenilin-1 | polymer | 467 | 52651.5 | 1 | UniProt (P49768) Pfam (PF01080) | Homo sapiens (Human) | PS-1,Protein S182 |
| 3 | C (C) | Gamma-secretase subunit APH-1A | polymer | 265 | 29017.9 | 1 | UniProt (Q96BI3) Pfam (PF06105) | Homo sapiens (Human) | APH-1a,Aph-1alpha,Presenilin-stabilization factor |
| 4 | D (D) | Gamma-secretase subunit PEN-2 | polymer | 101 | 12038.0 | 1 | UniProt (Q9NZ42) Pfam (PF10251) | Homo sapiens (Human) | Presenilin enhancer protein 2 |
| 5 | E (G) | POLY ALA CHAIN | polymer | 24 | 1723.9 | 1 | HOMO SAPIENS (HUMAN) |
Sequence modifications
B: 1 - 467 (UniProt: P49768)
| PDB | External Database | Details |
|---|---|---|
| Thr 256 | Tyr 256 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 173914.9 | |
| All* | Total formula weight | 173914.9 |
