5FN2
Cryo-EM structure of gamma secretase in complex with a drug DAPT
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Nicastrin | polymer | 709 | 78483.6 | 1 | UniProt (Q92542) Pfam (PF18266) Pfam (PF05450) In PDB | Homo sapiens (Human) | |
| 2 | B | Presenilin-1 | polymer | 467 | 52651.5 | 1 | UniProt (P49768) Pfam (PF01080) In PDB | Homo sapiens (Human) | PS-1,Protein S182 |
| 3 | C | Gamma-secretase subunit APH-1A | polymer | 265 | 29017.9 | 1 | UniProt (Q96BI3) Pfam (PF06105) In PDB | Homo sapiens (Human) | APH-1a,Aph-1alpha,Presenilin-stabilization factor |
| 4 | D | Gamma-secretase subunit PEN-2 | polymer | 101 | 12038.0 | 1 | UniProt (Q9NZ42) Pfam (PF10251) In PDB | Homo sapiens (Human) | Presenilin enhancer protein 2 |
Sequence modifications
B: 1 - 467 (UniProt: P49768)
| PDB | External Database | Details |
|---|---|---|
| Thr 256 | Tyr 256 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 172191.0 | |
| All* | Total formula weight | 172191.0 |
