5FLM

Structure of transcribing mammalian RNA polymerase II

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DNA-DIRECTED RNA POLYMERASE	polymer	1970	217436.1	1	Pfam (PF04997) Pfam (PF05001) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) Pfam (PF04992) Pfam (PF04990) UniProt (by SIFTS) (G3MZY8) In PDB	BOS TAURUS (BOVINE)
2	B	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2	polymer	1174	134041.4	1	UniProt (A5PJW8) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF04566) Pfam (PF04567) Pfam (PF00562) Pfam (PF04560) In PDB	BOS TAURUS (BOVINE)	DNA-DIRECTED RNA POLYMERASE II 140 KDA POLYPEPTIDE, DNA-DIRECTED RNA POLYMERASE II SUBUNIT B, RNA POLYMERASE II SUBUNIT 2, RNA POLYMERASE II SUBUNIT B2
3	C	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3	polymer	275	31466.1	1	UniProt (Q3T0Q3) Pfam (PF01193) Pfam (PF01000) In PDB	BOS TAURUS (BOVINE)	RNA POLYMERASE II SUBUNIT B3, DNA-DIRECTED RNA POLYMERASE II SUBUNIT C
4	D	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB4	polymer	142	16347.3	1	UniProt (Q1JQ91) Pfam (PF03874) In PDB	BOS TAURUS (BOVINE)	RNA POLYMERASE II SUBUNIT B4, DNA-DIRECTED RNA POLYMERASE II SUBUNIT D, RNA POLYMERASE II 16 KDA SUBUNIT, RPB16
5	E	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1	polymer	210	24514.2	1	UniProt (Q2T9T3) Pfam (PF03871) Pfam (PF01191) In PDB	BOS TAURUS (BOVINE)	RNA POLYMERASES I, II, AND III SUBUNIT ABC1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT E, RPB5 HOMOLOG
6	F	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2	polymer	127	14491.0	1	Pfam (PF01192) UniProt (by SIFTS) (Q32PE0) In PDB	BOS TAURUS (BOVINE)	RNA POLYMERASES I, II, AND III SUBUNIT ABC2, DNA-DIRECTED RNA POLYMERASE II SUBUNIT F, RPB6 HOMOLOG
7	G	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7	polymer	172	19314.3	1	UniProt (Q5E9B8) Pfam (PF03876) Pfam (PF00575) In PDB	BOS TAURUS (BOVINE)	RNA POLYMERASE II SUBUNIT B7, DNA-DIRECTED RNA POLYMERASE II SUBUNIT G
8	H	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3	polymer	150	17162.3	1	UniProt (F2Z4H3) Pfam (PF03870) In PDB	BOS TAURUS (BOVINE)	RNA POLYMERASES I, II, AND III SUBUNIT ABC3, DNA-DIRECTED RNA POLYMERASE II SUBUNIT H, DNA-DIRECTED RNA POLYMERASES I, AND III 17.1 KDA POLYPEPTIDE, RPB17, RPB8 HOMOLOG, HRPB8
9	I	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9	polymer	125	14507.2	1	UniProt (Q32P73) Pfam (PF02150) Pfam (PF01096) In PDB	BOS TAURUS (BOVINE)	RNA POLYMERASE II SUBUNIT B9, DNA-DIRECTED RNA POLYMERASE II SUBUNIT I
10	J	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5	polymer	67	7655.1	1	UniProt (Q32P78) Pfam (PF01194) In PDB	BOS TAURUS (BOVINE)	RNA POLYMERASES I, II, AND III SUBUNIT ABC5, DNA-DIRECTED RNA POLYMERASE III SUBUNIT L
11	K	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11	polymer	117	13310.3	1	UniProt (Q32P79) Pfam (PF13656) Pfam (PF01193) In PDB	BOS TAURUS (BOVINE)	RNA POLYMERASE II SUBUNIT B11, DNA-DIRECTED RNA POLYMERASE II SUBUNIT J
12	L	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC4	polymer	58	7018.2	1	UniProt (Q3ZBC0) Pfam (PF03604) In PDB	BOS TAURUS (BOVINE)	RNA POLYMERASES I, II, AND III SUBUNIT ABC4, DNA-DIRECTED RNA POLYMERASE II SUBUNIT K
13	N	DNA, DNA-RNA ELONGATION SCAFFOLD	polymer	39	12085.8	1		SYNTHETIC CONSTRUCT
14	P	RNA, DNA-RNA ELONGATION SCAFFOLD	polymer	20	6414.9	1		SYNTHETIC CONSTRUCT
15	T	DNA, DNA-RNA ELONGATION SCAFFOLD	polymer	39	11942.7	1		SYNTHETIC CONSTRUCT
16	A, B, C, I, J...	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
17	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Contents of the asymmetric unit

Polymers	Number of chains	15
	Total formula weight	547706.9
Non-Polymers*	Number of molecules	9
	Total formula weight	547.6
All*	Total formula weight	548254.5

*Water molecules are not included.