5FL5
Three dimensional structure of human carbonic anhydrase IX in complex with 5-(1-(4-Methoxyphenyl)-1H-1,2,3-triazol-4-yl)thiophene-2- sulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | CARBONIC ANHYDRASE IX | polymer | 257 | 28172.7 | 4 | UniProt (Q16790) Pfam (PF00194) | HOMO SAPIENS (HUMAN) | CARBONATE DEHYDRATASE IX, CARBONIC ANHYDRASE IX, CA-IX, CAI X, MEMBRANE ANTIGEN MN, P54/58N, RENAL CELL CARCINOMA-ASSOCIATED ANTIGEN G250, RCC-ASSOCIATED ANTIGEN G250, PMW1, CARBONIC ANHYDRASE IX |
| 2 | E, FA, Q, Z (A, D, B, C) | 5-[1-(4-methoxyphenyl)-1,2,3-triazol-4-yl]thiophene-2-sulfonamide | non-polymer | 336.4 | 4 | Chemie (82E) | |||
| 3 | AA, F, GA, R (C, A, D, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | BA, G, HA, S (C, A, D, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | CA, DA, EA, H, I... (C, A, D, B) | SULFATE ION | non-polymer | 96.1 | 19 | Chemie (SO4) | |||
| 6 | LA, P, Y (D, A, B) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 3 | Chemie (TRS) | |||
| 7 | MA, NA, OA, PA (A, B, C, D) | water | water | 18.0 | 901 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 5 - 259 (UniProt: Q16790)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Pro 4 | - | expression tag |
| Ser 42 | Cys 174 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 112690.7 | |
| Non-Polymers* | Number of molecules | 34 |
| Total formula weight | 4167.2 | |
| All* | Total formula weight | 116857.9 |
