5FHT
HtrA2 protease mutant V226K
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine protease HTRA2, mitochondrial | polymer | 334 | 36234.2 | 1 | UniProt (O43464) Pfam (PF13365) Pfam (PF17820) | Homo sapiens (Human) | High temperature requirement protein A2,HtrA2,Omi stress-regulated endoprotease,Serine protease 25,Serine proteinase OMI |
| 2 | B (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 5 | E (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | F (A) | water | water | 18.0 | 200 | Chemie (HOH) |
Sequence modifications
A: 1 - 325 (UniProt: O43464)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Lys 93 | Val 226 | engineered mutation |
| Ala 173 | Ser 306 | engineered mutation |
| Leu 326 | - | expression tag |
| Glu 327 | - | expression tag |
| His 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
| His 331 | - | expression tag |
| His 332 | - | expression tag |
| His 333 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36234.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 292.8 | |
| All* | Total formula weight | 36527.0 |
