5FGK

CDK8-CYCC IN COMPLEX WITH 8-[3-(3-Amino-1H-indazol-6-yl)-5-chloro- pyridine-4-yl]-2,8-diaza-spiro[4.5]decan-1-one

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cyclin-dependent kinase 8	polymer	364	42552.2	1	UniProt (P49336) Pfam (PF00069) In PDB	Homo sapiens (Human)	Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35
2	B	Cyclin-C	polymer	266	31541.1	1	UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB	Homo sapiens (Human)	SRB11 homolog,hSRB11
3	A	8-[3-(3-azanyl-2~{H}-indazol-6-yl)-5-chloranyl-pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one	non-polymer		396.9	1	Chemie (5XG)
4	A	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
5	A	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
6	A, B	FORMIC ACID	non-polymer		46.0	7	Chemie (FMT)
7		water	water		18.0	190	Chemie (HOH)

Sequence modifications

A: 1 - 362 (UniProt: P49336)

PDB	External Database	Details
Asp -1	-	expression tag
Lys 0	-	expression tag

B: 1 - 264 (UniProt: P24863)

PDB	External Database	Details
Lys -1	-	expression tag
Ala 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	74093.3
Non-Polymers*	Number of molecules	11
	Total formula weight	921.3
All*	Total formula weight	75014.6

*Water molecules are not included.