5FGK
CDK8-CYCC IN COMPLEX WITH 8-[3-(3-Amino-1H-indazol-6-yl)-5-chloro- pyridine-4-yl]-2,8-diaza-spiro[4.5]decan-1-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 8 | polymer | 364 | 42552.2 | 1 | UniProt (P49336) Pfam (PF00069) | Homo sapiens (Human) | Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35 |
| 2 | B (B) | Cyclin-C | polymer | 266 | 31541.1 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) | Homo sapiens (Human) | SRB11 homolog,hSRB11 |
| 3 | C (A) | 8-[3-(3-azanyl-2~{H}-indazol-6-yl)-5-chloranyl-pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one | non-polymer | 396.9 | 1 | Chemie (5XG) | |||
| 4 | D (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | E, L (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 6 | F, G, H, I, J... (A, B) | FORMIC ACID | non-polymer | 46.0 | 7 | Chemie (FMT) | |||
| 7 | N, O (A, B) | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
A: 1 - 362 (UniProt: P49336)
B: 1 - 264 (UniProt: P24863)
| PDB | External Database | Details |
|---|---|---|
| Asp -1 | - | expression tag |
| Lys 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Lys -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 74093.3 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 921.3 | |
| All* | Total formula weight | 75014.6 |
