5FEQ
EGFR KINASE DOMAIN IN COMPLEX WITH A COVALENT AMINOBENZIMIDAZOLE
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 328 | 37391.3 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | ~{N}-[1-[(3~{R})-1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-benzimidazol-2-yl]-2-methyl-pyridine-4-carboxamide | non-polymer | 474.6 | 1 | Chemie (5XH) | |||
3 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 696 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 695 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37391.3 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 474.6 | |
All* | Total formula weight | 37865.9 |