5FBV

PI4KB in complex with Rab11 and the MI364 Inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phosphatidylinositol 4-kinase beta,Phosphatidylinositol 4-kinase beta	polymer	572	65264.8	1	UniProt (Q9UBF8) Pfam (PF21245) Pfam (PF00454) In PDB	Homo sapiens (Human)	PtdIns 4-kinase beta,NPIK,PI4K92,PI4KB,PtdIns 4-kinase beta,NPIK,PI4K92,PI4KB
2	B	Ras-related protein Rab-11A	polymer	221	24813.0	1	UniProt (P62491) Pfam (PF00071) In PDB	Homo sapiens (Human)	Rab-11,YL8
3	A	~{N}-[2-[[6-chloranyl-3-[3-(2-hydroxyethylsulfamoyl)-4-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethy l]ethanamide	non-polymer		497.0	1	Chemie (5W3)
4	B	5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE	non-polymer		539.2	1	Chemie (GSP)

Sequence modifications

A: 128 - 522 (UniProt: Q9UBF8)
A: 523 - 799 (UniProt: Q9UBF8)
B: 1 - 216 (UniProt: P62491)

PDB	External Database	Details
Gly -4	-	expression tag
Ala -3	-	expression tag
Met -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Leu 70	Gln 70	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	90077.8
Non-Polymers*	Number of molecules	2
	Total formula weight	1036.2
All*	Total formula weight	91114.0

*Water molecules are not included.