5F72
De novo design and crystallographic validation of antibodies targeting a pre-selected epitope
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (K, C) | Kelch-like ECH-associated protein 1 | polymer | 296 | 32343.1 | 2 | UniProt (Q14145) Pfam (PF01344) | Homo sapiens (Human) | Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19 |
| 2 | C, D (T, S) | Single chain Fv from a Fab | polymer | 257 | 26620.3 | 2 | Homo sapiens (Human) | ||
| 3 | E, F, G, H (K, C, T, S) | water | water | 18.0 | 564 | Chemie (HOH) |
Sequence modifications
K, C: 321 - 611 (UniProt: Q14145)
| PDB | External Database | Details |
|---|---|---|
| Gly 316 | - | expression tag |
| Ser 317 | - | expression tag |
| Met 318 | - | expression tag |
| Gly 319 | - | expression tag |
| His 320 | - | expression tag |
| Asp 354 | Arg 354 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 117926.8 | |
| All* | Total formula weight | 117926.8 |
