5F5E
The Crystal Structure of MLL1 SET domain with N3816I/Q3867L mutation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Histone-lysine N-methyltransferase 2A | polymer | 158 | 18243.2 | 1 | UniProt (Q03164) Pfam (PF00856) In PDB | Homo sapiens (Human) | Lysine N-methyltransferase 2A,ALL-1,CXXC-type zinc finger protein 7,Myeloid/lymphoid or mixed-lineage leukemia,Myeloid/lymphoid or mixed-lineage leukemia protein 1,Trithorax-like protein,Zinc finger protein HRX |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A: 3813 - 3969 (UniProt: Q03164)
| PDB | External Database | Details |
|---|---|---|
| Ser 3812 | - | expression tag |
| Ile 3861 | Asn 3861 | engineered mutation |
| Leu 3867 | Gln 3867 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18243.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 449.8 | |
| All* | Total formula weight | 18693.0 |
