5F3E
Crystal structure of human KDM4A in complex with compound 54a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Lysine-specific demethylase 4A | polymer | 360 | 41854.6 | 4 | UniProt (O75164) Pfam (PF02375) Pfam (PF02373) | Homo sapiens (Human) | JmjC domain-containing histone demethylation protein 3A,Jumonji domain-containing protein 2A |
| 2 | E, F, I, J, M... (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | G, K, O, T (A, B, C, D) | 8-[4-[2-[4-(4-chlorophenyl)piperidin-1-yl]ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one | non-polymer | 434.9 | 4 | Chemie (5UO) | |||
| 4 | H, Q (A, C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 5 | L, P (B, C) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 6 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 1009 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 359 (UniProt: O75164)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 167418.5 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2603.4 | |
| All* | Total formula weight | 170021.9 |
