5F20
Structure of TYK2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (A) | Non-receptor tyrosine-protein kinase TYK2 | polymer | 301 | 34844.9 | 1 | UniProt (P29597) Pfam (PF07714) | Homo sapiens (Human) | |
2 | B (A) | 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one | non-polymer | 320.3 | 1 | Chemie (5U4) | |||
3 | C (A) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A: 884 - 1176 (UniProt: P29597)
PDB | External Database | Details |
---|---|---|
Met 882 | - | initiating methionine |
Gly 883 | - | expression tag |
Ser 1016 | Ala 1016 | conflict |
Asn 1023 | Asp 1023 | conflict |
His 1177 | - | expression tag |
His 1178 | - | expression tag |
His 1179 | - | expression tag |
His 1180 | - | expression tag |
His 1181 | - | expression tag |
His 1182 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 34844.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 320.3 | |
All* | Total formula weight | 35165.2 |