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5F20

Structure of TYK2 with inhibitor 4: 3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-one

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Non-receptor tyrosine-protein kinase TYK2polymer30134844.91UniProt (P29597)
Pfam (PF07714)
Homo sapiens (Human)
2B
(A)
3-azanyl-5-(2-methylphenyl)-7-(1-methylpyrazol-3-yl)-1~{H}-pyrazolo[4,3-c]pyridin-4-onenon-polymer320.31Chemie (5U4)
3C
(A)
waterwater18.031Chemie (HOH)
Sequence modifications
A: 884 - 1176 (UniProt: P29597)
PDBExternal DatabaseDetails
Met 882-initiating methionine
Gly 883-expression tag
Ser 1016Ala 1016conflict
Asn 1023Asp 1023conflict
His 1177-expression tag
His 1178-expression tag
His 1179-expression tag
His 1180-expression tag
His 1181-expression tag
His 1182-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight34844.9
Non-Polymers*Number of molecules1
Total formula weight320.3
All*Total formula weight35165.2
*Water molecules are not included.

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PDB entries from 2024-10-30

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