5F0M
Structure of retromer VPS26-VPS35 subunits bound to SNX3 and DMT1 (SeMet labeled)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vacuolar protein sorting-associated protein 35 | polymer | 462 | 53288.3 | 1 | UniProt (Q96QK1) Pfam (PF03635) | Homo sapiens (Human) | hVPS35,Maternal-embryonic 3,Vesicle protein sorting 35 |
| 2 | B (B) | Vacuolar protein sorting-associated protein 26A | polymer | 321 | 37913.3 | 1 | UniProt (O75436) Pfam (PF03643) | Homo sapiens (Human) | Vesicle protein sorting 26A,hVPS26 |
| 3 | C (C) | Sorting nexin-3 | polymer | 167 | 19193.8 | 1 | UniProt (O60493) Pfam (PF00787) | Homo sapiens (Human) | Protein SDP3 |
| 4 | D (D) | Natural resistance-associated macrophage protein 2 | polymer | 18 | 2218.3 | 1 | UniProt (P49281) | Homo sapiens (Human) | NRAMP 2,Divalent cation transporter 1,Divalent metal transporter 1,DMT-1,Solute carrier family 11 member 2 |
| 5 | E, F, M, V, W... (A, B, C) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 6 | G, H, N, Y, Z (A, B, C) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 7 | AA, I, J, K, L... (C, A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) |
Sequence modifications
A: 14 - 470 (UniProt: Q96QK1)
B: 2 - 321 (UniProt: O75436)
C: 1 - 162 (UniProt: O60493)
D: 549 - 560 (UniProt: P49281)
| PDB | External Database | Details |
|---|---|---|
| Gly 9 | - | expression tag |
| Ala 10 | - | expression tag |
| Met 11 | - | expression tag |
| Gly 12 | - | expression tag |
| Ser 13 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Mse 1 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 561 | - | expression tag |
| His 562 | - | expression tag |
| His 563 | - | expression tag |
| His 564 | - | expression tag |
| His 565 | - | expression tag |
| His 566 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 112613.7 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 1781.7 | |
| All* | Total formula weight | 114395.4 |
