5EYK
CRYSTAL STRUCTURE OF AURORA B IN COMPLEX WITH BI 847325
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Aurora kinase B-A | polymer | 276 | 32762.0 | 2 | UniProt (Q6DE08) Pfam (PF00069) | Xenopus laevis (African clawed frog) | Aurora/IPL1-related kinase 2-A,XAIRK2-A,Serine/threonine-protein kinase 12-A,Serine/threonine-protein kinase aurora-B-A,xAurora-B |
| 2 | C, D (C, D) | Inner centromere protein A | polymer | 59 | 7028.1 | 2 | UniProt (O13024) Pfam (PF03941) | Xenopus laevis (African clawed frog) | xIncenp,Mitotic phosphoprotein 130 |
| 3 | E, F (A, B) | 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide | non-polymer | 464.6 | 2 | Chemie (5U5) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 381 | Chemie (HOH) |
Sequence modifications
A, B: 81 - 356 (UniProt: Q6DE08)
C, D: 790 - 847 (UniProt: O13024)
| PDB | External Database | Details |
|---|---|---|
| Val 96 | Gly 96 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 789 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 79580.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 929.1 | |
| All* | Total formula weight | 80509.3 |
