5EWA
Crystal structure of the metallo-beta-lactamase IMP-1 in complex with the bisthiazolidine inhibitor L-VC26
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Beta-lactamase IMP-1 | polymer | 230 | 25300.8 | 4 | UniProt (P52699) Pfam (PF00753) | Serratia marcescens | BLAIMP,Beta-lactamase type II,Penicillinase. Metallo-beta-lactamase class B1 IMP-1 |
| 2 | E, F, I, J, L... (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | G, K, O, R (A, B, C, D) | (3~{R},5~{R},7~{a}~{S})-2,2-dimethyl-5-(sulfanylmethyl)-3,5,7,7~{a}-tetrahydro-[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid | non-polymer | 265.4 | 4 | Chemie (9BZ) | |||
| 4 | H (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | N (C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 306 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 228 (UniProt: P52699)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 101203.4 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 1725.1 | |
| All* | Total formula weight | 102928.5 |
