5EW9
Crystal Structure of Aurora A Kinase Domain Bound to MK-5108
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aurora kinase A | polymer | 271 | 31537.1 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (Human) | Aurora 2, Aurora/IPL1-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A |
| 2 | B (A) | 4-(3-chloranyl-2-fluoranyl-phenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid | non-polymer | 461.9 | 1 | Chemie (5VC) | |||
| 3 | C (A) | water | water | 18.0 | 74 | Chemie (HOH) |
Sequence modifications
A: 123 - 390 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 120 | - | expression tag |
| Pro 121 | - | expression tag |
| Gly 122 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31537.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 461.9 | |
| All* | Total formula weight | 31999.0 |
