5EV8
Crystal structure of the metallo-beta-lactamase IMP-1 in complex with the bisthiazolidine inhibitor D-CS319
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Beta-lactamase IMP-1 | polymer | 230 | 25300.8 | 4 | UniProt (P52699) Pfam (PF00753) | Serratia marcescens | BLAIMP,Beta-lactamase type II,Penicillinase |
| 2 | E, F, I, J, P... (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | G, H, K, R, Y (A, B, C, D) | (3S,5S,7aR)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid | non-polymer | 237.4 | 5 | Chemie (3R9) | |||
| 4 | L, M, N, S, Z (B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | O, T (B, C) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 6 | U (C) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 7 | V (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | AA, BA, CA, DA (A, B, C, D) | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 228 (UniProt: P52699)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 101203.4 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 2235.1 | |
| All* | Total formula weight | 103438.5 |
