5EUB

Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 2-amino-MTA and sulfate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	S-methyl-5'-thioadenosine phosphorylase	polymer	297	33119.1	1	UniProt (Q13126) Pfam (PF01048)	Homo sapiens (Human)	5'-methylthioadenosine phosphorylase,MTAPase
2	B, C (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	D (A)	(2~{R},3~{R},4~{S},5~{S})-2-[2,6-bis(azanyl)purin-9-yl]-5-(methylsulfanylmethyl)oxolane-3,4-diol	non-polymer		312.3	1	Chemie (5S7)
4	E (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
5	F, G (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
6	H (A)	water	water		18.0	180	Chemie (HOH)

Sequence modifications

A: 1 - 283 (UniProt: Q13126)

PDB	External Database	Details
Met -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33119.1
Non-Polymers*	Number of molecules	6
	Total formula weight	724.1
All*	Total formula weight	33843.2

*Water molecules are not included.