5ES4
RE-REFINEMENT OF INTEGRIN ALPHAXBETA2 ECTODOMAIN IN THE CLOSED/BENT CONFORMATION
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Integrin alpha-X | polymer | 1137 | 125606.4 | 4 | UniProt (P20702) Pfam (PF00092) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF21520) | Homo sapiens (Human) | CD11 antigen-like family member C,Leu M5,Leukocyte adhesion glycoprotein p150,95 alpha chain,Leukocyte adhesion receptor p150,95 |
| 2 | B, D, F, H (B, D, F, H) | Integrin beta-2 | polymer | 727 | 80630.7 | 4 | UniProt (P05107) Pfam (PF17205) Pfam (PF00362) Pfam (PF07965) | Homo sapiens (Human) | Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta,Complement receptor C3 subunit beta |
| 3 | I (I) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G94626GC) | |||
| 4 | J (J) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G85238RP) | |||
| 5 | K, T, X (K, T, X) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G22573RC) | |||
| 6 | L (L) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 7 | M (M) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 8 | N, S (N, S) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
| 9 | O (O) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G92805XC) | |||
| 10 | P (P) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G10756ZZ) | |||
| 11 | Q, U, V (Q, U, V) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 12 | R (R) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G34442SS) | |||
| 13 | W (W) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G23799GS) | |||
| 14 | Y (Y) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G42227JK) | |||
| 15 | AA, BA, BB, FB, GB... (A, F, G, B, C...) | CALCIUM ION | non-polymer | 40.1 | 16 | Chemie (CA) | |||
| 16 | CA (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 17 | AB, CB, DA, DB, EA... (E, F, A, B, G...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 27 | Chemie (NAG) | |||
| 18 | RB, SB, TB, UB, VB... (A, B, C, D, E...) | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 1 - 1084 (UniProt: P20702)
B, D, F, H: 1 - 674 (UniProt: P05107)
| PDB | External Database | Details |
|---|---|---|
| Gly 1085 | - | expression tag |
| Cys 1086 | - | expression tag |
| Gly 1087 | - | expression tag |
| Gly 1088 | - | expression tag |
| Leu 1089 | - | expression tag |
| Glu 1090 | - | expression tag |
| Asn 1091 | - | expression tag |
| Leu 1092 | - | expression tag |
| Tyr 1093 | - | expression tag |
| Phe 1094 | - | expression tag |
| Gln 1095 | - | expression tag |
| Gly 1096 | - | expression tag |
| Gly 1097 | - | expression tag |
| Glu 1098 | - | expression tag |
| Asn 1099 | - | expression tag |
| Ala 1100 | - | expression tag |
| Gln 1101 | - | expression tag |
| Cys 1102 | - | expression tag |
| Glu 1103 | - | expression tag |
| Lys 1104 | - | expression tag |
| Glu 1105 | - | expression tag |
| Leu 1106 | - | expression tag |
| Gln 1107 | - | expression tag |
| Ala 1108 | - | expression tag |
| Leu 1109 | - | expression tag |
| Glu 1110 | - | expression tag |
| Lys 1111 | - | expression tag |
| Glu 1112 | - | expression tag |
| Asn 1113 | - | expression tag |
| Ala 1114 | - | expression tag |
| Gln 1115 | - | expression tag |
| Leu 1116 | - | expression tag |
| Glu 1117 | - | expression tag |
| Trp 1118 | - | expression tag |
| Glu 1119 | - | expression tag |
| Leu 1120 | - | expression tag |
| Gln 1121 | - | expression tag |
| Ala 1122 | - | expression tag |
| Leu 1123 | - | expression tag |
| Glu 1124 | - | expression tag |
| Lys 1125 | - | expression tag |
| Glu 1126 | - | expression tag |
| Leu 1127 | - | expression tag |
| Ala 1128 | - | expression tag |
| Gln 1129 | - | expression tag |
| Trp 1130 | - | expression tag |
| Ser 1131 | - | expression tag |
| His 1132 | - | expression tag |
| Pro 1133 | - | expression tag |
| Gln 1134 | - | expression tag |
| Phe 1135 | - | expression tag |
| Glu 1136 | - | expression tag |
| Lys 1137 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 675 | - | expression tag |
| Gly 676 | - | expression tag |
| Cys 677 | - | expression tag |
| Gly 678 | - | expression tag |
| Leu 679 | - | expression tag |
| Glu 680 | - | expression tag |
| Asn 681 | - | expression tag |
| Leu 682 | - | expression tag |
| Tyr 683 | - | expression tag |
| Phe 684 | - | expression tag |
| Gln 685 | - | expression tag |
| Gly 686 | - | expression tag |
| Gly 687 | - | expression tag |
| Lys 688 | - | expression tag |
| Asn 689 | - | expression tag |
| Ala 690 | - | expression tag |
| Gln 691 | - | expression tag |
| Cys 692 | - | expression tag |
| Lys 693 | - | expression tag |
| Lys 694 | - | expression tag |
| Lys 695 | - | expression tag |
| Leu 696 | - | expression tag |
| Gln 697 | - | expression tag |
| Ala 698 | - | expression tag |
| Leu 699 | - | expression tag |
| Lys 700 | - | expression tag |
| Lys 701 | - | expression tag |
| Lys 702 | - | expression tag |
| Asn 703 | - | expression tag |
| Ala 704 | - | expression tag |
| Gln 705 | - | expression tag |
| Leu 706 | - | expression tag |
| Lys 707 | - | expression tag |
| Trp 708 | - | expression tag |
| Lys 709 | - | expression tag |
| Leu 710 | - | expression tag |
| Gln 711 | - | expression tag |
| Ala 712 | - | expression tag |
| Leu 713 | - | expression tag |
| Lys 714 | - | expression tag |
| Lys 715 | - | expression tag |
| Lys 716 | - | expression tag |
| Leu 717 | - | expression tag |
| Ala 718 | - | expression tag |
| Gln 719 | - | expression tag |
| Gly 720 | - | expression tag |
| Gly 721 | - | expression tag |
| His 722 | - | expression tag |
| His 723 | - | expression tag |
| His 724 | - | expression tag |
| His 725 | - | expression tag |
| His 726 | - | expression tag |
| His 727 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 824948.5 | |
| Branched | Number of molecules | 17 |
| Total formula weight | 15484.0 | |
| Non-Polymers* | Number of molecules | 44 |
| Total formula weight | 6638.2 | |
| All* | Total formula weight | 847070.7 |
