5EOB

Crystal structure of CMET in complex with novel inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hepatocyte growth factor receptor	polymer	319	36033.6	1	UniProt (P08581) Pfam (PF07714) In PDB	Homo sapiens (Human)	HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met
2	A	6-[bis(fluoranyl)-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline	non-polymer		392.3	1	Chemie (5QQ)
3		water	water		18.0	119	Chemie (HOH)

Sequence modifications

A: 1038 - 1346 (UniProt: P08581)

PDB	External Database	Details
Met 1028	-	initiating methionine
Gly 1029	-	expression tag
Ser 1030	-	expression tag
Ser 1031	-	expression tag
His 1032	-	expression tag
His 1033	-	expression tag
His 1034	-	expression tag
His 1035	-	expression tag
His 1036	-	expression tag
His 1037	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	36033.6
Non-Polymers*	Number of molecules	1
	Total formula weight	392.3
All*	Total formula weight	36425.9

*Water molecules are not included.