5EOB
Crystal structure of CMET in complex with novel inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 319 | 36033.6 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (Human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | B (A) | 6-[bis(fluoranyl)-[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline | non-polymer | 392.3 | 1 | Chemie (5QQ) | |||
| 3 | C (A) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A: 1038 - 1346 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Met 1028 | - | initiating methionine |
| Gly 1029 | - | expression tag |
| Ser 1030 | - | expression tag |
| Ser 1031 | - | expression tag |
| His 1032 | - | expression tag |
| His 1033 | - | expression tag |
| His 1034 | - | expression tag |
| His 1035 | - | expression tag |
| His 1036 | - | expression tag |
| His 1037 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36033.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 392.3 | |
| All* | Total formula weight | 36425.9 |
