5ENJ
Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with compound-14 N11530 (SGC - Diamond I04-1 fragment screening)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PH-interacting protein | polymer | 131 | 15594.7 | 1 | UniProt (Q8WWQ0) Pfam (PF00439) | Homo sapiens (Human) | PHIP,IRS-1 PH domain-binding protein,WD repeat-containing protein 11 |
| 2 | B (A) | ~{N}-[[2,6-bis(chloranyl)phenyl]methyl]-~{N}-methyl-ethanamide | non-polymer | 232.1 | 1 | Chemie (5Q9) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A: 1315 - 1440 (UniProt: Q8WWQ0)
| PDB | External Database | Details |
|---|---|---|
| Tyr 1310 | - | expression tag |
| Phe 1311 | - | expression tag |
| Gln 1312 | - | expression tag |
| Ser 1313 | - | expression tag |
| Met 1314 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15594.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 256.4 | |
| All* | Total formula weight | 15851.1 |
