5EI1
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the imidazopyridine derivative 2-(4-hydroxyphenyl)-3-iodanyl-imidazo[1,2-a]pyridin-6-ol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Estrogen receptor | polymer | 257 | 29299.5 | 2 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D | NCOA2 | polymer | 14 | 1666.9 | 2 | UniProt (by SIFTS) (Q15596) In PDB | Homo sapiens | |
| 3 | A, B | 2-(4-hydroxyphenyl)-3-iodanyl-imidazo[1,2-a]pyridin-6-ol | non-polymer | 352.1 | 2 | Chemie (5OR) | |||
| 4 | water | water | 18.0 | 155 | Chemie (HOH) |
Sequence modifications
A, B: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 61933.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 704.3 | |
| All* | Total formula weight | 62637.2 |
