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5EHR

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP099

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BTyrosine-protein phosphatase non-receptor type 11polymer52660335.02UniProt (Q06124)
Pfam (PF00017)
Pfam (PF00102)
In PDB
Homo sapiens (Human)Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,Shp2,SH-PTP3
2A, B6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-aminenon-polymer352.32Chemie (5OD)
3A, BPHOSPHATE IONnon-polymer95.06Chemie (PO4)
4waterwater18.0670Chemie (HOH)
Sequence modifications
A, B: 1 - 525 (UniProt: Q06124)
PDBExternal DatabaseDetails
Ser 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight120670.1
Non-Polymers*Number of molecules8
Total formula weight1274.3
All*Total formula weight121944.4
*Water molecules are not included.

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PDB entries from 2024-08-28

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