5EG9

The cap binding site of influenza virus protein PB2 as a drug target

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Polymerase basic protein 2	polymer	183	20497.7	2	UniProt (Q6DNL8) Pfam (PF00604)	Influenza A virus	RNA-directed RNA polymerase subunit P3,RNA-directed RNA polymerase subunit P3
2	C, D (A, B)	water	water		18.0	63	Chemie (HOH)

Sequence modifications

A, B: 318 - 420 (UniProt: Q6DNL8)

PDB	External Database	Details
Met 297	-	initiating methionine
Gly 298	-	expression tag
Ser 299	-	expression tag
Ser 300	-	expression tag
His 301	-	expression tag
His 302	-	expression tag
His 303	-	expression tag
His 304	-	expression tag
His 305	-	expression tag
His 306	-	expression tag
Ser 307	-	expression tag
Ser 308	-	expression tag
Gly 309	-	expression tag
Leu 310	-	expression tag
Val 311	-	expression tag
Pro 312	-	expression tag
Arg 313	-	expression tag
Gly 314	-	expression tag
Ser 315	-	expression tag
His 316	-	expression tag
Met 317	-	expression tag

A, B: 424 - 479 (UniProt: Q6DNL8)

PDB	External Database	Details
Gly 421	-	linker
Ser 422	-	linker
Gly 423	-	linker
Ser 449	Pro 453	conflict
Ile 474	Val 478	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	40995.4
All*	Total formula weight	40995.4

*Water molecules are not included.