5EFN
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (H574A) in complex with histone H4 Lys6 tripeptide substrate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (B, A) | Hdac6 protein | polymer | 364 | 40218.4 | 2 | UniProt (A7YT55) Pfam (PF00850) UniProt (by SIFTS) (F8W4B7) | Danio rerio (Zebrafish) | histone deacetylase 6 |
| 2 | B, D (F, E) | histone H4 tripeptide | polymer | 3 | 420.5 | 2 | Homo sapiens | ||
| 3 | E, K (B, A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, G, L, M (B, A) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 5 | H, I, N (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | J, O (F, E) | 7-AMINO-4-METHYL-CHROMEN-2-ONE | non-polymer | 175.2 | 2 | Chemie (MCM) | |||
| 7 | P, Q, R (B, A, E) | water | water | 18.0 | 634 | Chemie (HOH) |
Sequence modifications
B, A: 440 - 798 (UniProt: A7YT55)
| PDB | External Database | Details |
|---|---|---|
| Ser 435 | - | expression tag |
| Asn 436 | - | expression tag |
| Ala 437 | - | expression tag |
| Gly 438 | - | expression tag |
| Gly 439 | - | expression tag |
| Ala 574 | His 422 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 81277.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 823.8 | |
| All* | Total formula weight | 82101.6 |
