5EDQ
EGFR kinase (T790M/L858R) with inhibitor compound 15: ~{N}-(7-chloranyl-1~{H}-indazol-3-yl)-7,7-dimethyl-2-(1~{H}-pyrazol-4-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Epidermal growth factor receptor | polymer | 331 | 37549.4 | 1 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | A | ~{N}-(7-chloranyl-1~{H}-indazol-3-yl)-7,7-dimethyl-2-(1~{H}-pyrazol-4-yl)-5~{H}-furo[3,4-d]pyrimidin-4-amine | non-polymer | 381.8 | 1 | Chemie (5N3) |
Sequence modifications
A: 695 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 694 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Arg 858 | Leu 858 | engineered mutation |
Ala 865 | Glu 865 | engineered mutation |
Ala 866 | Glu 866 | engineered mutation |
Ala 867 | Lys 867 | engineered mutation |
Asn 1023 | - | expression tag |
Ser 1024 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37549.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 381.8 | |
All* | Total formula weight | 37931.2 |