5EBT
Tankyrase 1 with Phthalazinone 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Tankyrase-1 | polymer | 210 | 24140.4 | 4 | UniProt (O95271) Pfam (PF00644) | Homo sapiens (Human) | TANK1,ADP-ribosyltransferase diphtheria toxin-like 5,ARTD5,Poly [ADP-ribose] polymerase 5A,TNKS-1,TRF1-interacting ankyrin-related ADP-ribose polymerase,Tankyrase I |
| 2 | E, J (A, C) | (R,R)-2,3-BUTANEDIOL | non-polymer | 90.1 | 2 | Chemie (BU3) | |||
| 3 | F, H, K, N (A, B, C, D) | 4-[bis(fluoranyl)-[3-[[(6~{S})-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]methyl]-2~{H}-phthalazin-1-one | non-polymer | 504.4 | 4 | Chemie (5N8) | |||
| 4 | G, I, L, M (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 5 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 378 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1106 - 1314 (UniProt: O95271)
| PDB | External Database | Details |
|---|---|---|
| Met 1105 | - | initiating methionine |
| Ile 1266 | Met 1266 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96561.7 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2459.5 | |
| All* | Total formula weight | 99021.3 |
