5EAK
Optimization of Microtubule Affinity Regulating Kinase (MARK) Inhibitors with Improved Physical Properties
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase MARK2 | polymer | 328 | 37832.7 | 2 | UniProt (Q7KZI7) Pfam (PF00069) Pfam (PF00627) | Homo sapiens (Human) | ELKL motif kinase 1,EMK-1,MAP/microtubule affinity-regulating kinase 2,PAR1 homolog,PAR1 homolog b,Par1b |
| 2 | C, D (A, B) | N-[(1S,2R)-2-aminocyclohexyl]-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide | non-polymer | 421.5 | 2 | Chemie (24R) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B: 39 - 364 (UniProt: Q7KZI7)
| PDB | External Database | Details |
|---|---|---|
| Lys 37 | - | expression tag |
| Leu 38 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75665.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 843.0 | |
| All* | Total formula weight | 76508.5 |
