5E90
TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D,I211V,Y249F, S280T,Y282F,S287N,A350C,L352F) IN COMPLEX WITH 3-AMINO-6- [4-(2-HYDROXYETHYL)PHENYL]-N-[4-(MORPHOLIN-4-YL)PYRIDIN-3-YL]PYRAZINE-2-CARBOXAMIDE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TGF-beta receptor type-1 | polymer | 307 | 35226.6 | 1 | UniProt (P36897) Pfam (PF00069) | Homo sapiens (Human) | TGFR-1,Activin A receptor type II-like protein kinase of 53kD,Activin receptor-like kinase 5,ALK5,Serine/threonine-protein kinase receptor R4,SKR4,TGF-beta type I receptor,Transforming growth factor-beta receptor type I,TbetaR-I |
| 2 | B (A) | 3-amino-6-[4-(2-hydroxyethyl)phenyl]-N-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide | non-polymer | 420.5 | 1 | Chemie (5L4) | |||
| 3 | C (A) | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
A: 200 - 503 (UniProt: P36897)
| PDB | External Database | Details |
|---|---|---|
| Gly 197 | - | expression tag |
| His 198 | - | expression tag |
| Met 199 | - | expression tag |
| Asp 204 | Thr 204 | engineered mutation |
| Val 211 | Ile 211 | engineered mutation |
| Phe 249 | Tyr 249 | engineered mutation |
| Thr 280 | Ser 280 | engineered mutation |
| Phe 282 | Tyr 282 | engineered mutation |
| Asn 287 | Ser 287 | engineered mutation |
| Cys 350 | Ala 350 | engineered mutation |
| Phe 352 | Leu 352 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35226.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 420.5 | |
| All* | Total formula weight | 35647.0 |
