5E8Y
TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH STAUROSPORINE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TGF-beta receptor type-2 | polymer | 316 | 35840.7 | 1 | UniProt (P37173) Pfam (PF07714) | Homo sapiens (Human) | TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II,TbetaR-II |
| 2 | B (A) | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) | |||
| 3 | C (A) | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 237 - 549 (UniProt: P37173)
| PDB | External Database | Details |
|---|---|---|
| Gly 234 | - | expression tag |
| His 235 | - | expression tag |
| Met 236 | - | expression tag |
| Ala 431 | Glu 431 | engineered mutation |
| Ala 433 | Arg 433 | engineered mutation |
| Ala 485 | Glu 485 | engineered mutation |
| Ala 488 | Lys 488 | engineered mutation |
| Ala 493 | Arg 493 | engineered mutation |
| Ala 495 | Arg 495 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35840.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 466.5 | |
| All* | Total formula weight | 36307.2 |
