5E8Y
TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN (E431A,R433A,E485A,K488A,R493A,R495A) IN COMPLEX WITH STAUROSPORINE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TGF-beta receptor type-2 | polymer | 316 | 35840.7 | 1 | UniProt (P37173) Pfam (PF07714) | Homo sapiens (Human) | TGFR-2,TGF-beta type II receptor,Transforming growth factor-beta receptor type II,TbetaR-II |
| 2 | B (A) | STAUROSPORINE | non-polymer | 466.5 | 1 | Chemie (STU) PubChem (5279) PubChem (44259) PubChem (71203703) PubChem (42610657) PubChem (44299148) PubChem (25322871) PubChem (28684983) PubChem (451705) PubChem (44120114) PubChem (44537813) PubChem (49831000) PubChem (46864193) PubChem (68262703) PubChem (68306294) PubChem (5459111) PubChem (73953205) PubChem (6419748) PubChem (86306248) PubChem (358479) PubChem (9804568) PubChem (9937179) PubChem (5280487) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (122130844) PubChem (12046017) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 3 | C (A) | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 237 - 549 (UniProt: P37173)
| PDB | External Database | Details |
|---|---|---|
| Gly 234 | - | expression tag |
| His 235 | - | expression tag |
| Met 236 | - | expression tag |
| Ala 431 | Glu 431 | engineered mutation |
| Ala 433 | Arg 433 | engineered mutation |
| Ala 485 | Glu 485 | engineered mutation |
| Ala 488 | Lys 488 | engineered mutation |
| Ala 493 | Arg 493 | engineered mutation |
| Ala 495 | Arg 495 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35840.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 466.5 | |
| All* | Total formula weight | 36307.2 |
