5E89
Crystal structure of Human galectin-3 CRD in complex with 3-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Galectin-3 | polymer | 139 | 15758.1 | 1 | UniProt (P17931) Pfam (PF00337) | Homo sapiens (Human) | Gal-3,35 kDa lectin,Carbohydrate-binding protein 35,CBP 35,Galactose-specific lectin 3,Galactoside-binding protein,GALBP,IgE-binding protein,L-31,Laminin-binding protein,Lectin L-29,Mac-2 antigen |
| 2 | B (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 3 | C (A) | 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside | non-polymer | 648.6 | 1 | Chemie (TD2) PubChem (73774610) PubChem (90109156) PubChem (118436792) PubChem (118679947) PubChem (118657353) PubChem (122418481) PubChem (126624445) PubChem (126624423) PubChem (130471368) PubChem (118404248) PubChem (118408645) PubChem (118507865) PubChem (134692124) PubChem (118680035) PubChem (126624426) PubChem (129261745) PubChem (140639477) PubChem (140820580) PubChem (145121529) PubChem (153447831) PubChem (173976503) PubChem (173733738) PubChem (173742413) | |||
| 4 | D (A) | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A: 114 - 250 (UniProt: P17931)
| PDB | External Database | Details |
|---|---|---|
| Gly 112 | - | expression tag |
| Pro 113 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15758.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 684.1 | |
| All* | Total formula weight | 16442.2 |
